Метод і система лазерної поляриметрії для оцінювання патологічних змін біологічних тканин

Abstract

This dissertation is devoted to the further development of the theory of optical polarization measurements in biomedicine, deepening and further development of existing and development of new theoretical statements, methods and models of laser polarimetry to improve the reliability of the results of evaluation of structural changes in biological tissues by anisotropic polarimetric development of methods of analysis and differentiation of pathological changes. The work presents a new method for polarimetric analysis of anisotropic biological tissues by determining surface averaged local anisotropy parameters, entropy and the degree of polarization by using Mueller matrix elements of individual types of anisotropy of the sample in accordance with its classification, proposed a new method of differentiation of pathological changes in optically anisotropic biological tissues which are determined by laser polarization sensing of tissue segments from Mueller matrix analysis of local anisotropy parameters, entropy and the degree of polarization with the application of adaptive fuzzy analysis, improved mathematical model of random photons transfer in plane-parallel sample of skin based on Monte Carlo method taking into account the state of polarization of the probing light. The practical significance of the results is the overall direction of the applied results, which are used for laser polarimetric analysis of structural changes in anisotropic BT for the detection and evaluation of pathology in medical diagnosis of skin diseases.