Апаратно-програмний комплекс для моніторингу та управління глікемічним профілем

Abstract

The dissertation presents the results of studies to increase the information content of the process of monitoring and management of glycemic profile in patients with type I diabetes mellitus by developing a method, model and hardware and software complex. The basis of the artificial pancreas is the bio cybernetic concept of the hardware-software complex for monitoring and management of the glycemic profile, characterized by three basic prerequisites. The first process of changing the glycemic profile is one that is self-regulating only in the mode of special indicators in the process. The secondary premise is that traditional insulin therapy functions as an artificial regulator that connects in parallel to the natural and corrects defects in the body. The decision maker for managing the patient's glycemic profile is the doctor who performs it, receiving relevant glycemic data. Finally, the third prerequisite that distinguishes the hardware and software complex for monitoring and managing the glycemic profile from the artificial beta cell is the presence of biomedical feedback, which performs the functions of controlling the patient's response to insulin therapy and generates suggestions and recommendations for correction and support blood glucose is normal. A mathematical model of the process of monitoring and management of the glycemic profile of a patient with type I diabetes has been developed for the first time on the basis of an improved mathematical model of M.J. Davis, which has been improved in the part of minimizing the time delay of the signal on changes of insulin dose from 5 - 15 minutes to 3 - 4 minutes by continuous monitoring of glucose biosensor monitoring and blood glucose adjustments after ingestion. Created a method of determining the psychological personalized status of a patient as a mandatory component of the medical-diagnostic process of severely ill type I diabetes has been developed. Combined method of monitoring and determining the level of glucose in human blood is proposed, presented by a set of methods for determining the level of glucose in the air exhaled by the patient, a method for evaluating emotional stress according to the parameters of the photo method of similarity of the form of the photo to the exemplary patterns, which are completely consistent presented, interactive process, assessment of the physiological parameters of the glycemic profile, provides continuous and monitoring and management of the glycemic profile of the patient. It be experimentally established that to create a biosensor measuring glucose that will meet the full set of required characteristics is possible only on condition that such a biosensor is an integral multi sensor. Further development was achieved by the complex of functional capabilities of existing devices such as Artificial Beta by supplementing it with new features. It is also proposed to expand the structure of the Artificial Beta system by introducing a psychological support unit.